Prevalence and Some Associated Risk Factors of Maxillary Sinus Mucous Retention Cyst in Panoramic View of Patients Referred to Radiology Department of Mashhad Dental School-Iran 2007
Mahrokh
ImaniMoghaddam
Associate Professer, Dept of Oral & Maxillofacial Radiology, School of Dentistry and Dental Research Center of Mashhad University of Medical Sciences, Mashhad, Iran
author
Ali
Bagherpour
Assistant Professor, Dept of Oral & Maxillofacial Radiology, School of Dentistry and Dental Research Center of Mashhad University of Medical Sciences, Mashhad, Iran
author
Azam
AhmadianYazdi
Instructor, Dept of Oral & Maxillofacial Radiology, School of Dentistry and Dental Research Center of Mashhad University of Medical Sciences, Mashhad, Iran
author
Nazanin
Qmarci
Postgraduate Student, Dept of Operative Dentistry, Dental School, Shiraz University of Medical Sciences, Shiraz, Iran
author
text
article
2009
per
Introduction: Mucous retention cyst (MRC) is the most common complication of sinusitis. It rarely causes any sign or symptom. The purpose of this study was to determine the prevalence and some associated risk factors of (MRC) in panoramic view in patients referring to the radiology department of Mashhad dental school.
Materials & Methods: In this study, panoramic radiographs of 707 patients referring to the radiology department of Mashhad dental school were examined for detection of well defined, not corticated, smooth, dome-shaped radiopaque mass in maxillary sinus for one year and mucous retention cyst prevalence and some associated risk factors such as age, sex, site of occurrence, allergy and smoking habit were evaluated. The data were statistically analyzed by chi-square and t-tests.
Results: From 707 patients examined, 36 patients (5.1%) had mucous retention cyst in their maxillary sinuses, 20 patients in right maxillary sinuses (55.6%); 13 patients in left (31.6%) and in 3 patients, MRC were bilateral (8.3%). According to this study, these cysts were most common in the third and Fifth decades. The Fisher’s exact test showed that there was a statistically significant association between allergy and occurrence of MRC (P<0.001).
Conclusion: The results of this study were similar to previous studies. Occurrence of MRC had a statistically significant association with allergy but the association between age, sex, smoking and presence of MRC was not significant.
Journal of Mashhad Dental School
Mashhad University of Medical Sciences, School of Dentistry
1560-9286
33
v.
2
no.
2009
89
96
https://jmds.mums.ac.ir/article_1273_043c8ad7abde88bcdd303f139ee53bcf.pdf
dx.doi.org/10.22038/jmds.2009.1273
Effect of the Electrical Versus Manual Tooth Brush on Oral Hygiene Indices in Patients Treated with Fixed Orthodontic Appliances
SeyedAli
Banihashemrad
Assistant Professor, Dept of Periodontics, School of Dentistry and Dental Research Center of Mashhad University of Medical Sciences, Mashhad, Iran
author
Arezoo
Jahanbin
Assistant Professor, Dept of Orthodontics, School of Dentistry and Dental Research Center of Mashhad University of Medical Sciences, Mashhad, Iran
author
Habibollah
Esmaili
Associate Professor, Dept of Biostatistics, School of Medicine and Neonatal Research Center of Mashhad University of Medical Sciences, Mashhad, Iran
author
Minoo
SanaeeMoghadam
Dentist
author
text
article
2009
per
Introduction: For preventing plaque accumulation side effects, oral hygiene performance by patients, especially adolescents who are the main part of orthodontic patients, is necessary. Considering several studies indicating the efficacy of electric toothbrush usage on periodontal health, the aim of this study was to evaluate the efficacy of electric toothbrush on oral hygiene indices in patients treated with fixed orthodontic appliances.
Materials & Methods: In this clinical trial study, 40 orthodontic patients (aged 12 to 20 years old) wearing upper and lower fixed appliances for at least 6 months who had a history of at least two time inappropriate oral hygiene were selected. Control group patients used two kind of orthodontic manual toothbrushes of Oral-B and Colgate total toothpaste for 4 weeks. Case group patients used electric toothbrush (Cross Action Power) of Oral-B and Colgate total toothpaste for 4 weeks. At baseline and after 4 weeks, ortho-plaque index (OPl) and bleeding points index (BPI) were measured. The data were analyzed by paired t-test, independent t-test and Chi-square test.
Results: After intervention, in control group, OPI reduced by 19.9% and in case group it had 13.2% reduction. BPI was reduced in case and control groups by 8.5% and 20% respectively. In contrast to BPI (P=0.003), t-test showed that there were no significant differences between two groups in OPI reduction (P=0.11).
Conclusion: The result of our study showed that electric toothbrush had no significant advantage over manual toothbrush. Manual brushing was even more effective than cross action power tooth brush in BPI reduction.
Journal of Mashhad Dental School
Mashhad University of Medical Sciences, School of Dentistry
1560-9286
33
v.
2
no.
2009
97
106
https://jmds.mums.ac.ir/article_1274_33a0d08cf7ee69d43248fe33c70c9aba.pdf
dx.doi.org/10.22038/jmds.2009.1274
Evaluation of General Dentists Knowledge about Oral Cancer in Mashhad-Iran in 2008
Shadi
Saghafi
Assistant Professor, Dept of Oral Pathology, School of Dentistry and Dental Research Center of Mashhad University of Medical Sciences, Mashhad, Iran
author
Reza
ZareMahmoodabadi
Assistant Professor, Dept of Oral Pathology, School of Dentistry and Dental Research Center of Mashhad University of Medical Sciences, Mashhad, Iran
author
Jahanshah
Salehinejad
Associate Professor, Dept of Oral Pathology, School of Dentistry and Dental Research Center of Mashhad University of Medical Sciences, Mashhad, Iran
author
Farnaz
Falaki
Assistant Professor, Dept of Oral Medicine, School of Dentistry and Dental Research Center of Mashhad University of Medical Sciences, Mashhad, Iran
author
Shahab
Farrokhizad
Dentist
author
text
article
2009
per
Introduction: Oral cancer is one of the most prevalent cancers and one of the 10 most Familiar causes of death in the whole world. Most oral cancers are diagnosed at late stages. Since dentists play a critical role in early detection of oral cancers, they should be knowledgeable and skillful in oral cancer diagnosis. The aim of this study was to evaluate the knowledge of general dentists about oral cancer in Mashhad.
Materials & Methods: This descriptive cross-sectional study was done on 100 general dentists who had private offices in Mashhad in 2008. A questionnaire including demographic information and 13 questions regarding oral cancer was prepared. The questionnaires were delivered to dentists at their offices and then gathered. The data were analyzed via SPSS software by student’s t-test, Pearson and Spearman correlation coefficients.
Results: There were 65 male and 35 female dentists with the mean age of 41.84±7.49 years (P=0.66). The mean score of total dentists’ knowledge was 6.42±1.74 out of 13. The mean score of knowledge was 6.26±1.75 and 6.72±1.7, for males and females respectively. There was no significant difference between them (P=0.2). Ninety-One percent of dentists knew the most common type of oral cancer, but only 35% of them knew the most common sites of oral cancer.
Conclusion: The results of this study indicated that knowledge of dentists in Mashhad about oral cancer was not sufficient.Because of the importance of the issue, application of strategies to increase the knowledge of dentists regarding oral cancer is necessary.
Journal of Mashhad Dental School
Mashhad University of Medical Sciences, School of Dentistry
1560-9286
33
v.
2
no.
2009
107
114
https://jmds.mums.ac.ir/article_1275_aec4db5d777843b851f3c2257bc7534b.pdf
dx.doi.org/10.22038/jmds.2009.1275
Evaluation of Maxillomandibular Fixation Screws in the Management of Mandibular Fractures
Ataollah
Habibi
Associate Professor, Dept of Oral & Maxillofacial Surgery, School of Dentistry and Dental Research Center of Mashhad University of Medical Sciences, Mashhad, Iran
author
Amin
RahPeyma
Assistant Professor, Dept of Oral & Maxillofacial Surgery, School of Dentistry and Dental Research Center of Mashhad University of Medical Sciences, Mashhad, Iran
author
AliReza
HalajMofrad
Postgraduate Student, Dept of Oral & Maxillofacial Surgery, Dental School, Mashhad University of Medical Sciences, Mashhad, Iran
author
text
article
2009
per
Introduction: The use of maxillomandibular fixation screws (MMFS) has become increasingly popular in maxillofacial surgery. This method does not have many of the disadvantages of the arch bar. However, use of this method has not been studied well. The aim of this study was to evaluate the efficacy of fixation and adaptation by means of screw in mandibular fractures.
Materials & Methods: In this clinical trial study, approved by ethical committee of Mashhad University of Medical Sciences, maxillomandibular fixation self-tapping screws were used in 28 patients. At least 2 screws were inserted in each jaw and jointed together with wires. The jaws were fixed for 4 weeks in the normal occlusion. Frequency of fracture healing in terms of fracture location as well as healing at fracture sites and frequency of nerve and tooth injury resulting from screw insertion were recorded.
Results: Except for one case that developed mild open bite, the other 27 patients were recuperated in function and appearance. There were no dental or sensory complications.
Conclusion: Considering the advantages of MMFS in mandibular fracture fixation, application of this device as an alternative to traditional therapy is recommended.
Journal of Mashhad Dental School
Mashhad University of Medical Sciences, School of Dentistry
1560-9286
33
v.
2
no.
2009
115
120
https://jmds.mums.ac.ir/article_1276_66fda159b86c001870b6abfd3a73a788.pdf
dx.doi.org/10.22038/jmds.2009.1276
Accuracy of Conventional Radiography in Differentiating Between Benign Lesions and Malignant Ones in the Maxillofacial Region
SayedHossein
HosseiniZarch
Assistant Professor, Dept of Maxillofacial Radiology, School of Dentistry and Dental Research Center of Mashhad University of Medical Sciences, Mashhad, Iran
author
Adineh
JavadianLangaroodi
Postgraduate Student, Dept of Maxillofacial Radiology, Dental School, Mashhad University of Medical Sciences, Mashhad, Iran
author
Amir
TavassoliNoghabi
Dentist
author
text
article
2009
per
Introduction: In the maxillofacial region, cysts and tumors relatively have high prevalence and during a current study of radiography, the dentists may incidentally encounter them. According to the wide usage of the conventional panoramic radiography in routine study of dentoalveolar structure and the availability and cheapness of this technique, it seems necessary to determine the accuracy of conventional radiography in diagnosis of benign and malignant lesions.
Materials & Methods: In this descriptive study, all the cases with intraosseous lesions of maxillofacial region over a six-year period (2002-2008) from the archives of the radiography, surgery and oral health departments at Mashhad school of dentistry were collected. Then radiographic images were studied by one maxillofacial radiologist as an observer and according to the radiographic features, the state of being malignant or benign and then the type of lesions were diagnosed. Finally the findings of radiographic and histopathologic studies were compared using McNemar test.
Results: From 136 intraosseous lesions, 116 lesions were benign and 20 lesions were malignant. From 20 malignant lesions, in 19 cases the radiographic and histopathologic diagnosis was the same and from the 116 benign lesions, 107 cases were diagnosed benign in radiography. A significant relationship was also detected among radiographic and histopathologic features (P=0.021).
Conclusion: In this study diagnosis of conventional radiographies, in 92% of cases, with histopathologic results (benignity or malignancy of lesions) was adapted.
Journal of Mashhad Dental School
Mashhad University of Medical Sciences, School of Dentistry
1560-9286
33
v.
2
no.
2009
121
128
https://jmds.mums.ac.ir/article_1277_345a1b1deb453d348241de45615b5515.pdf
dx.doi.org/10.22038/jmds.2009.1277
Five Year's Retrospective Study of Oral and Maxillofacial Malignancies in Patients Referred to Oral Medicine Department of Mashhad Dental School-Iran
Zahra
Delavarian
Associate Professor, Dept of Oral Medicine, School of Dentistry and Dental Research Center of Mashhad University of Medical Sciences,Mashhad, Iran
author
Atessa
Pakfetrat
Assistant Professor Dept of Oral Medicine, School of Dentistry and Dental Research Center of Mashhad University of Medical Sciences, Mashhad, Iran
author
SayedMostafa
Mahmoudi
Postgraduate Student, Dept of Oral Pathology, Dental School, Tabriz University of Medical Sciences, Tabriz, Iran
author
text
article
2009
per
Introduction: In spite of recent progresses in cancer treatment; the oral cancer is still one of ten most common causes of death, because of late diagnosis (the reasons for that is similarity of clinical presentation with some of the benign lesions, symptomless in early stages, and variety of clinical manifestation…). Considering the role of cultural and geographical factors in oral cancer prevalence, epidemiological studies are of great importance. The aim of this research is to determine five years prevalence of orofacial malignancies of the patients referred to Oral Medicine Department, Mashhad Dental School, Iran.
Materials & Methods: A descriptive and retrospective study was done using 44 medical files of patients whose oral and maxillofacial malignancy was histopothologically confirmed. (From November 2000 to November 2005) demographic, clinical and histopathological data were extracted. We’ve used SPSS software to analyze data and drawing table and charts.
Results: Squamous cell carcinoma (SCC) was the most common malignancy (73%) followed by verrucous carcinoma (10%) and salivary gland carcinoma (7%). Male to female ratio was 0.9/1 and age average was 53.52±17.66. The most common clinical feature of SCC was ulcer and exophytic lesion (%34) and other malignancy mostly appeared as exophytic lesion (%67). The most prevalent chief complains of oral SCC patients was ulcer (41%), and tongue was the most common site (30%).
Conclusion: Although most of epidemiological patterns of oral SCC were similar to other researches, but females had a higher incidence rate than males and surprisingly tobacco use was markedly low in comparison to other studies.
Journal of Mashhad Dental School
Mashhad University of Medical Sciences, School of Dentistry
1560-9286
33
v.
2
no.
2009
129
138
https://jmds.mums.ac.ir/article_1278_1ee424c263ee83dc409453f076a85d15.pdf
dx.doi.org/10.22038/jmds.2009.1278
The Prophylactic Effect of Toothguard in Prevention of Dental Trauma during Laryngoscopy in Patients Undergoing General Anesthesia
MohammadReza
SabzAliZanjankhah
Assistant Professor, Dept of Anesthesia, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
author
AliReza
Bamshki
Assistant Professor, Dept of Anesthesia, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
author
Hossein
AhmadiFard
Postgraduate Student, Dept of Anesthesia, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
author
Mohammad
Goharian
Dental student, Dental School, Mashhad University of Medical Sciences, Mashhad, Iran
author
text
article
2009
per
Introduction: Dental trauma during general anesthesia is common and is the most frequent complication of endotracheal intubation. The purpose of this study was to evaluate dental trauma in laryngoscope and prophylactic effect of toothguard on prevention in patients undergoing general aesthesia.
Materials & Methods: In this clinical trial study, approved by ethical committee of Mashhad University of Medical Sciences, 240 patients undergoing general anesthesia and tracheal intubation (120 patients with toothguard and 120 patients without toothguard) were studied. In preoperative and postoperative management, medical history was obtained and physical examination was performed. Variables in this study were age, sex, preoperative and postoperative dental examinations and mallampathi and laryngoscopy scores. Data were analyzed by Fisher's exact test. The level of significance was set at 0.05.
Result: Dental injury was 0.8% frequent in tooth guard group and 5.8% in without toothguard group (P=0.02). There was a significant difference in dental trauma in patients with displaced tooth between the two groups (P=0.013). Results showed that in patients with mallampathi and laryogoscopy scores of III or IV, dental trauma was more frequent in patients without toothguard (P=0.03 and 0.04, respectively).
Conclusion: Dental shields are useful to reduce the force applied to the teeth and potentially reduce the probability of tooth damage during laryngoscopy in patients with difficult intubation and mallampathi and larynogoscopy scores of III and IV.
Journal of Mashhad Dental School
Mashhad University of Medical Sciences, School of Dentistry
1560-9286
33
v.
2
no.
2009
139
144
https://jmds.mums.ac.ir/article_1279_8d3abdb3ee9431833e1e9cb11d2ee101.pdf
dx.doi.org/10.22038/jmds.2009.1279
Evaluation of MDM2 and P53 Expression in Dentigerous, Radicular and Residual Cysts by Immunuhistochemistry
Nasrollah
Saghravanian
Assistant Professor, Dept of Oral and Maxillofacial Pathology, School of Dentistry and Dental Research Center of Mashhad University of Medical Sciences, Mashhad, Iran
author
Atoollah
Habibi
Associate Professor, Dept of Oral & Maxillofacial Surgery, School of Dentistry and Dental Research Center of Mashhad University of Medical Sciences, Mashhad, Iran.
author
Nooshin
Mohtasham
Associate Professor, Dept of Oral and Maxillofacial Pathology, School of Dentistry and Dental Research Center of Mashhad University of Medical Sciences, Mashhad, Iran
author
Monavar
AfzalAghaie
Social Medicine Specialist, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
author
Atena
Shiva
Postgraduate Student, Dept of Oral and Maxillofacial Pathology, Dental School, Mashhad University of Medical Sciences, Mashhad, Iran
author
Sahar
Babazadeh
Dentist
author
text
article
2009
per
Introduction: Dentigerous cyst (the most common developmental cyst), periapical cyst (the most common jaw cyst) and residual cyst may transfer to neoplasm. In this study, the expression of P53 & MDM2 (cell proliferative regulators) and their relation to proliferation and transformation of these cysts were evaluated.
Materials & Methods: In this cross-sectional study, expressions of P53 and MDM2 markers in 60 samples of paraffin blocks (20 samples for each cyst) were examined by Immunohistochemistry method and the percentage, intensity, and location of involved epithelial cells were evaluated. Statistical tests included one way ANOVA and Tukey test for evaluation of expression, and Kruskal-Wallis for intensity comparison and Kendall for detecting correlation between markers.
Results: Periapical cyst showed complete expression of markers. Severity, percentage and depth of MDM2 expression were higher than P53. Marker expression for residual cyst was highly intensive and also in full thickness of epithelium, but it was basillary with lower intensity in dentigerous cyst. Expression of P53 and MDM2 had significant differences in these three cysts (P=0.01,0.03 respectively), and also significant difference for percentage and severity of MDM2 between the three groups (P=0.003,0.001 respectively). There was a positive linear correlation between P53 and MDM2 expression (P<0.001).
Conclusion: In residual cyst, there was a correlation between increase in MDM2and P53 expression, but not in periapical cyst. Dentigerous cyst failed to strongly express each of the markers. Nevertheless, it could be said that increase in expression of these markers could be related to pathogenesis and neoplastic transformation of these cysts.
Journal of Mashhad Dental School
Mashhad University of Medical Sciences, School of Dentistry
1560-9286
33
v.
2
no.
2009
145
152
https://jmds.mums.ac.ir/article_1280_0cc7996a6ea9175b185fbf75806e1792.pdf
dx.doi.org/10.22038/jmds.2009.1280
Resonance Frequency Analysis of Implant Clinical Stability on Astra tech and ITI Implant Systems
Naser
Sargolzaie
Associate Professor, Dept of Periodontology, School of Dentistry and Dental Research Center of Masshad University of Medical Sciences, Mashhad, Iran
author
Amir
MoeinTagavi
Associate Professor, Dept of Periodontology, School of Dentistry and Dental Research Center of Masshad University of Medical Sciences, Mashhad, Iran
author
Mehrdad
Radvar
Associate Professor, Dept of Periodontology, School of Dentistry and Dental Research Center of Masshad University of Medical Sciences, Mashhad, Iran
author
HamidReza
Arab
Associate Professor, Dept of Periodontology, School of Dentistry and Dental Research Center of Masshad University of Medical Sciences, Mashhad, Iran
author
MajidReza
Mokhtari
Postgraduate Student, Dept of Periodontology, Dental School, Mashhad University of Medical Sciences, Mashhad, Iran
author
text
article
2009
per
Introduction: Resonance frequency analysis (FRA) offers a clinical, noninvasive measurement of stability and osseointegration of implants. The RFA values are represented by a quantitative unit called the Implant stability quotient (ISQ) on a scale from1 to 100. The objective of the present study was to measure the stability of Astra tech and ITI dental implants during the healing period and determine the factors that affect the ISQ.
Materials & Methods: In this clinical trial study, approved by ethical committee of Mashhad University of Medical Sciences, 14 healthy subjects candidate for dental implants were randomly divided into two groups. Group one received 15 Astra tech and group two received 15 ITI dental implants. ISQ was used for direct measurement of implant stability on the day of implant placement and first, third and sixth month after implant placement. Data were analyzed by student-t test and ANOVA and Spearman Rank Correlation Test through SPSS 11.5 with 95% confidence interval.
Results: The mean ISQ of Astra Tech implant at third and sixth month were significantly greater than ITI implant (P=0.001 and P=0.018, respectively). Statistical analysis showed higher ISQ values for mandible than maxilla (P=0.001). Bone quality significantly affected ISQ value and implant diameter was significantly correlated to implant stability (P=0.02).
Conclusion: Our results showed that Astra tech implants had significantly greater ISQs in third and sixth month than ITI implants. Furthermore, bone quality, implant surface texture (implant system) and diameter can affect implant stability and time of loading.
Journal of Mashhad Dental School
Mashhad University of Medical Sciences, School of Dentistry
1560-9286
33
v.
2
no.
2009
153
160
https://jmds.mums.ac.ir/article_1281_f2619c80485bafff1bd47d0eaf71dcbf.pdf
dx.doi.org/10.22038/jmds.2009.1281
Wear Rate of Four Kinds of Artificial Teeth in Artificial Saliva Invironment (An In Vitro Study)
Jafar
Gharehchahi
Professor, Dept of Prosthodontics, School of Dentistry and Dental Research Center of Mashhad University of Medical Sciences, Mashhad, Iran
author
Fatemeh
Rostamkhani
Associate Professor, Dept of Prosthodontics, School of Dentistry and Dental Research Center of Mashhad University of Medical Sciences, Mashhad, Iran
author
Mohammad
Asadollahzadeh
Prosthodontist
author
SeyedMojtaba
Zebarjad
Associate Professor, Dept of Metallurgy, School of Engineering, Ferdowsi University, Mashhad, Iran
author
text
article
2009
per
Introduction: Wear resistance of acrylic teeth has an important role in denture longevity. The purpose of this study was to compare the tooth wear rate of three kinds of artificial teeth manufactured in Iran with the one manufactured in Italy.
Materials & Methods: In this experimental in vitro study, four kinds of artificial teeth (Italian Ivoclar, Yaghoot, Herasit plus, Acradent) were used. Nine molars were selected from each tooth. Samples were prepared as cylinders with 2.5mm diameters. The samples were thermocycled for 2500 times (5˚C-55˚C) and then scaled with 1/100000 gram accuracy. Artificial saliva was added to wearing device and wearing was performed for 2000 cycles (125m). Samples were rescaled. The disk and saliva were exchanged and the procedure was repeated for 5000 cycles (439.6m). The rescaling was as well performed. Wear rate was calculated for 2000 and 7000 cycles and was compared for different teeth. The data were analysed by Multivariate ANOVA and Tukey test.
Results: Tooth wear after 2000 cycles was 0.018 for Ivoclar, 0.025 for yaghoot, 0.071 for Acradent and 0.379 mgr/m for Herasit. After 7000 Cycles, wear rates were 0.012, 0.019, 0.055 and 0.14 mgr/m respectively.
Conclusion: Wear rate of Herasit and Acradent artificial teeth were significantly different from eachother and from Yaghoot and Ivoclar artificial teeth but Yaghoot and Ivoclar teeth had no significant difference in wear rate.
Journal of Mashhad Dental School
Mashhad University of Medical Sciences, School of Dentistry
1560-9286
33
v.
2
no.
2009
161
168
https://jmds.mums.ac.ir/article_1282_0a5cd4589111f9c3ac127d36004565b0.pdf
dx.doi.org/10.22038/jmds.2009.1282
Evaluation of P53 and PCNA Expression in Oral Leukoplakic Lesions with and without Epithelial Dysplasia by Immunohistochemistry Technique
Nooshin
Mohtasham
Associate Professor, Dept of Oral and Maxillofacial Pathology, School of Dentistry and Dental Research Center of Mashhad University of Medical Sciences, Mashhad, Iran
author
Nasrollah
Saghravanian
Assistant Professor, Dept of Oral and Maxillofacial Pathology, School of Dentistry and Dental Research Center of Mashhad University of Medical Sciences, Mashhad, Iran
author
Noorieh
Sharifi
Associate Professor, Dept of Pathology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
author
MohammadTaghi
Shakeri
Associate Professor, Dept of Epidemiology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
author
Shima
AmelGarieb
Dentist
author
Setareh
Shojaee
Postgraduate Student, Dept of Oral and Maxillofacial Pathology, Dental School, Mashhad University of Medical Sciences, Mashhad, Iran
author
text
article
2009
per
Introduction: Leukoplakia is the most common precancerous lesion of the oral mucosa and may range microscopically form benign hyperkeratosis to invasive squamous cell carcinoma. P53 is a tumor suppressor protein; whereas, proliferative cell nuclear antigen (PCNA) is a proliferative marker. The aim of this study was to evaluate the immunohistochemical expressions of P53 and PCNA in oral leukoplakia with and without dysplasia.
Materials & Methods: The expression of P53 and PCNA proteins were determined immunohistochemically in paraffin sections of 53 leukoplakias (17 without dyplasia, 15 with mild dysplasia, 14 with moderate dysplasia and 7 with severe dysplasia), in addition to 10 normal oral mucosa. Statistical analysis was performed using One-Way ANOVA, Kruskal-Wallis, and spearman tests.
Results: P53 protein was expressed in 60% of normal oral mucosa, 82.4% of leukoplakias without dysplasia and 100% of leukoplakias with dysplasia. PCNA protein was expressed in all of the specimens. There were statistical differences between P53 and PCNA expression among normal mucosa, leukoplakias with and without dysplasia, regarding their grading and severity (P<0.001). There was a positive correlation between P53 and PCNA expression.
Conclusion: Increase in P53 and PCNA expression is related to the degree of dysplasia in oral leukoplakias. Therefore, we can use these markers in order to indicate and grade dysplastic lesions more exactly. PCNA and P53 could also be used as appropriate markers to estimate the potential of malignant transformation in oral leukoplakia lesions.
Journal of Mashhad Dental School
Mashhad University of Medical Sciences, School of Dentistry
1560-9286
33
v.
2
no.
2009
169
176
https://jmds.mums.ac.ir/article_1283_466b9c761bfe2a43399d03f934634089.pdf
dx.doi.org/10.22038/jmds.2009.1283
Using the Stereolithographic Surgical Guide Templates in Implant Surgery; A Case Report
Abbas
Azari
Assistant Professor, Dept of Prosthetics, Dental School, Tehran University of Medical Sciences, Tehran, Iran
author
Sakineh
Nikzad
Assistant Professor, Dept of Prosthetics, Dental School, Tehran University of Medical Sciences, Tehran, Iran
author
text
article
2009
per
Introduction: Computer guided implantology (CGI) is the state of the art in modern implantology. In this article, based upon this newly developed concept, the step by step treatment sequences of an upper jaw of a patient with dental implant was demonstrated.
Results: Based upon CGI treatment protocols, implantation was performed for a 49 years old man with upper jaw tooth loss. Data from CTscan led to preparation of exact surgical templates (stereolithographic surgical templates) for implant placement. It was found that due to more precise location of implant placed, the prosthetic phase of treatment would be simplified and the esthetics could be fully achievable.
Conclusion: Computer guided implantology may be an excellent tool in achieving best treatment planing, esthetics and precise implant placement.
Journal of Mashhad Dental School
Mashhad University of Medical Sciences, School of Dentistry
1560-9286
33
v.
2
no.
2009
177
182
https://jmds.mums.ac.ir/article_1284_3c25c4a962e37d999a8cc533b611326a.pdf
dx.doi.org/10.22038/jmds.2009.1284